What is the Early Prevention of Obesity Childhood (EPOCH) Trial repository?

 

The EPOCH trial repository is a listing of intervention trials which have been designed to prevent obesity in early childhood and beyond.

 

We collate information from randomised trials where the trials have introduced preventive measures which may impact on child's growth and development.

 

Inclusion criteria

 

To be included in the repository, trials must:

  1. be randomised trials
  2. have the main aim of the intervention to prevent childhood obesity
  3. start interventions in the first two years of childhood or prior to this
  4. continue interventions for at least 6 months postnatally
  5. undertake implementation of an intervention that includes a component related to lifestyle (e.g. early feeding, parenting, physical activity, sleep).
  6. have a follow up time of at least 2 years.

 

Aims of the repository

 

The primary aims of the repository are to:

  1. Identify potential research areas: summarising and describing intervention trials in progress can make it easier to identify gaps in trial research in this critical area.
  2. To promote research collaboration: enabling researchers and health care practitioners to identify trials in which they may have an interest could result in more effective collaboration among researchers.
  3. To improve trial quality: sharing information may lead to improvements in the quality of trials by making it possible to identify the best tools to use and measurements to take

 

To be included in our repository please provide the following information:

 

  • name
  • trial registration number
  • objectives
  • main design features
  • sample size and recruitment status
  • treatments/interventions under investigation
  • outcomes being assessed
  • principal investigators
  • contact details for specific trial information

 

In the future we plan to form a collaboration of early prevention of childhood obesity researchers and eventually pool data to inform evidence based policy.

Trial details

 The trials are listed below and further details of trails are available here. (updated February 2020)

No

Trial name

Country

Design

Link to protocol

1

The Sleeping and Intake Methods Taught to Infants and Mothers Early in Life (SLIMTIME) Project

US

Randomised, crossover

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477360/

 

2

The Healthy Lifestyles Passport Program: a Nutrition Education Program to Prevent Childhood Obesity (HLPP)

US

Randomised, parallel

No protocol published but details of trial available https://clinicaltrials.gov/ct2/show/NCT01649115

 

3

PRIMROSE: Primary prevention of childhood obesity at child health centers

Sweden

Cluster-randomized

http://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-335

 

4

Preventing Childhood Obesity Through Early Guidance

US

Randomised, parallel

http://www.ncbi.nlm.nih.gov/pubmed/24063435

 

5

Early Stockholm Obesity Prevention Program (Early STOPP)

Sweden

Randomised, parallel

http://www.ncbi.nlm.nih.gov/pubmed/21592388

 

6

Addressing Health Literacy and Numeracy to Prevent Childhood Obesity (Greenlight)

US

Randomised, parallel

http://pediatrics.aappublications.org/content/133/6/e1724.short

 

7

Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT)

US

Randomised, parallel

https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-14-184

 

8

INFANT Extend

Australia

Cluster randomised

https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-2836-0

9

Translating research evidence from the Healthy Beginnings Trial to prevent childhood obesity at the beginning of life:  feasibility effectiveness and cost effectiveness.

Australia

Randomised parallel

https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-4005-x

10

Starting Early Obesity Prevention Program

United States

Randomised parallel

https://clinicaltrials.gov/ct2/show/NCT01541761

11

Feeding Young Children Study: Bottle Weaning Intervention (NCT00756626)

 United States Randomised parallel  

https://clinicaltrials.gov/ct2/show/NCT00756626

https://www.ncbi.nlm.nih.gov/pubmed/24183206

12

 Prevention of Obesity in Toddlers (PROBIT) Trial (NCT03131284)  Italy Randomised parallel  https://clinicaltrials.gov/ct2/show/NCT03131284

13

The BeeBOFT Study (NTR1831)

 Netherlands  Cluster RCT

https://www.ncbi.nlm.nih.gov/pubmed/24138805

https://www.ncbi.nlm.nih.gov/pubmed/28751299

14

Preventing Early Childhood Obesity, Part 2: Family Spirit Nurture, Prenatal - 18 Months

USA Randomised, parallel  

https://clinicaltrials.gov/ct2/show/NCT03334266

15

 Effectiveness of a Motivational Interviewing-based Intervention From Pregnancy to 2 Years of Age. (PROGESPI)  Spain Cluster RCT   

https://clinicaltrials.gov/ct2/show/NCT03444415

16

 Addressing Health Literacy and Numeracy to Prevent Childhood Obesity  USA  Randomised, parallel  

https://clinicaltrials.gov/ct2/show/NCT03370445

17

 Baby's First Bites: Promoting Vegetable Intake in Infants and Toddlers  Netherlands  Randomised, factorial  

https://clinicaltrials.gov/ct2/show/NCT03348176

18

 Strong Futures: A Trial of Two Primary Care Based Interventions to Promote Optimal Health in Latino Infants and Toddlers  USA  Randomised, parallel  

https://clinicaltrials.gov/ct2/show/NCT03438721

19

 "Samen Happie!" An mHealth intervention to prevent obesity through parenting  The Netherlands  Randomised, parallel  

http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6938

 20 Baby-led introduction to solids (BLISS) New Zealand Randomised, parallel

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363183&isReview=true

Protocol

https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-015-0491-8

 

21 SCHeLTI (Sino-Canadian Healthy Life Trajectory Initiative) China Cluster randomised

http://www.chictr.org.cn/showprojen.aspx?proj=30062

22 SPOON: Sustained Program for Improving Nutrition - Guatemala Guatemala Randomised, parallel

https://clinicaltrials.gov/ct2/show/NCT03399617

23 SPOON:Sustained Program for Improving Nutrition - Mexico (SPOON-Mexico) Mexico Randomised, parallel

https://clinicaltrials.gov/ct2/show/NCT03752762

24 Greenlight Plus Study:  Approaches to Early Childhood Obesity Prevention USA Randomised, parallel

https://clinicaltrials.gov/ct2/show/NCT04042467

https://www.pcori.org/research-results/2018/greenlight-plus-study-randomized-study-approaches-early-childhood-obesity

25 Early Obesity Prevention:  A randomised trial of a practice-based intervention in 0-24 month infants USA randomised, cluster-stratified clinical trial https://www.hindawi.com/journals/jobe/2015/795859/
26 Obesity and Caries in Young South Asian Children: A Common Risk Factor Approach (CHALO) USA randomised, parallel

https://clinicaltrials.gov/ct2/show/NCT03077425

https://www.ncbi.nlm.nih.gov/pubmed/29855352?dopt=Abstract